How I manage cyclic thrombocytopenia

Abstract Cyclic thrombocytopenia (CTP) is a rare disease, which characterized by periodic fluctuation of the platelet count. The pathogenesis CTP unknown and most likely heterogeneous. Patients with are almost always misdiagnosed as having primary immune (ITP). interval between ITP diagnosis can be many years. patients often receive ITP-specific therapies including corticosteroids, thrombopoietin receptor agonists, rituximab, splenectomy, followed transient increase in count that wrongly attributed to treatment effect inevitable “relapse.” diagnosed frequent monitoring, reveals typical pattern cycling. An early will prevent these from being exposed possibly harmful therapies. bleeding phenotype usually mild consists mucocutaneous at time when its nadir. Severe other sites occur but rare. Some respond cyclosporine A or danazol, do not any therapy. associated hematological malignancies disorders thyroid gland. Nevertheless, spontaneous remissions occur, even after